The following list comprises a list of publications to which members of the ASI team have contributed.

Catalogued into subject areas for ease of reference, copies are available upon specific request, subject to copyright terms and conditions.



Johnston A, Holt DW. Substandard drugs: a potential crisis for public health. Br J Clin Pharmacol. 2013 Nov 29. [Epub ahead of print].


Annesley TM, McKeown DA, Holt DW, Mussell C, Champarnaud E, Harter L, Calton LJ, Mason DS. Standardization of LC-MS for therapeutic drug monitoring of tacrolimus. Clin Chem. 2013 Nov;59(11):1630-7.

El-Sayed AA, Mohamed KM, Nasser AY, Button J, Holt DW. Simultaneous determination of tramadol, O-desmethyltramadol and N-desmethyltramadol in human urine by gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 1;926:9-15.

Levine DM, Maine GT, Armbruster DA, Mussell C, Buchholz C, O’Connor G, Tuck V, Johnston A, Holt DW. The need for standardization of tacrolimus assays. Clin Chem. 2011 Dec;57(12):1739-47.

Annesley TM, McKeown DA, Holt DW, Mussell C, Champarnaud


Spierings N, Holt DW, MacPhee IA. CYP3A5 genotype had no impact on intrapatient variability of tacrolimus clearance in renal transplant recipients. Ther Drug Monit. 2013 Jun;35(3):328-31.

Fredericks S, Fitzgerald L, Shaw G, Holt DW. Changes in salivary immunoglobulin A (IgA) following match-play and training among English premiership footballers. Med J Malaysia. 2012 Apr;67(2):155-8.

Kirwan CJ, MacPhee IA, Lee T, Holt DW, Philips BJ. Acute kidney injury reduces the hepatic metabolism of midazolam in critically ill patients. Intensive Care Med. 2012 Jan;38(1):76-84.

Jamshidi Y, Moreton M, McKeown DA, Andrews S, Nithiyananthan T, Tinworth L, Holt DW, Sadiq ST. Tribal ethnicity and CYP2B6 genetics in Ugandan and Zimbabwean populations in the UK: implications for efavirenz dosing in HIV infection. J Antimicrob Chemother. 2010 Dec;65(12):2614-9.

McKeown DA, Rosenvinge M, Donaghy S, Sharland M, Holt DW, Cormack I, Hay P, Sadiq ST. High neonatal concentrations of raltegravir following transplacental transfer in HIV-1 positive pregnant women. AIDS. 2010 Sep 24;24(15):2416-8.

 Kuypers DR, Le Meur Y, Cantarovich M, Tredger MJ, Tett SE, Cattaneo D, Tönshoff B, Holt DW, Chapman J, Gelder Tv; Transplantation Society (TTS) Consensus Group on TDM of MPA. Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation. Clin J Am Soc Nephrol. 2010 Feb;5(2):341-58.

Johnston A. Equivalence and interchangeability of narrow therapeutic index drugs in organ transplantation. Eur J Hosp Pharm Sci Pract. 2013 Oct;20(5):302-307.   Al Ameri MN, Mohamed W, Makramalla E, Shalhoub B, Tucker A, Johnston A. Renal patients’ views on generic prescribing and substitution: example from the United Arab Emirates. East Mediterr Health J. 2013 Apr;19(4):373-81.

Boyce M, David O, Darwin K, Mitchell T, Johnston A, Warrington S. Single oral doses of netazepide (YF476), a gastrin receptor antagonist, cause dose-dependent, sustained increases in gastric pH compared with placebo and ranitidine in healthy subjects. Aliment Pharmacol Ther. 2012 Jul;36(2):181-9.

Al Ameri MN, Whittaker C, Tucker A, Yaqoob M, Johnston A. A survey to determine the views of renal transplant patients on generic substitution in the UK. Transpl Int. 2011 Aug;24(8):770-9.

Johnston A, Asmar R, Dahlöf B, Hill K, Jones DA, Jordan J, Livingston M, Macgregor G, Sobanja M, Stafylas P, Rosei EA, Zamorano J. Generic and therapeutic substitution: a viewpoint on achieving best practice in Europe. Br J Clin Pharmacol. 2011 Nov;72(5):727-30.
AlAmeri M, Epstein M, Johnston A. Generic and therapeutic substitutions: are they always ethical in their own terms? Pharm World Sci. 2010 Dec;32(6):691-5.

Couchman L, Morgan PE, Spencer EP, Johnston A, Flanagan RJ. Plasma clozapine and norclozapine in patients prescribed different brands of clozapine (Clozaril, Denzapine, and Zaponex). Ther Drug Monit. 2010 Oct;32(5):624-7.

Chik Z, Tucker AT, Shiel JI, Collier DJ, Perrett D, Lee TD, Johnston A. Comparative pharmacokinetic assessments of topical drugs: evaluation by dermatopharmacokinetics, microdialysis, and systemic measurement. J Invest Dermatol. 2010 Dec;130(12):2828-30.
Chew AL, Bashir SJ, Johnston A, Barker JN, Smith CH. The value of monitoring ciclosporin concentration 2 hours post-dose (C2) in dermatology: a prospective cohort study. J Dermatolog Treat. 2011 Apr;22(2):79-85.

Tucker A, Maass A, Bain D, Chen LH, Azzam M, Dawson H, Johnston A. Augmentation of venous, arterial and microvascular blood supply in the leg by isometric neuromuscular stimulation via the peroneal nerve. Int J Angiol. 2010 Spring;19(1):e31-7.

Johnston A. Challenges of therapeutic substitution of drugs for economic reasons: focus on CVD prevention. Curr Med Res Opin. 2010 Apr;26(4):871-8.
Chik Z, Johnston A, Tucker AT, Kirby K, Alam CA. Correcting endogenous concentrations of testosterone influences bioequivalence and shows the superiority of TDS(R)-testosterone versus Androgel(R). Int J Clin Pharmacol Ther. 2009 Apr;47(4):262-8.

Wallemacq P, Armstrong VW, Brunet M, Haufroid V, Holt DW, Johnston A, Kuypers D, Le Meur Y, Marquet P, Oellerich M, Thervet E, Toenshoff B, Undre N, Weber LT, Westley IS, Mourad M. Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference. Ther Drug Monit. 2009 Apr;31(2):139-52.


Murray DB, Potts S, Haxton C, Jackson G, Sandilands EA, Ramsey J, Puchnarewicz M, Holt DW, Johnston A, Nicholas Bateman D, Dear JW. ‘Ivory wave’ toxicity in recreational drug users; integration of clinical and poisons information services to manage legal high poisoning. Clin Toxicol (Phila). 2012 Feb;50(2):108-13.

Wood DM, Davies S, Cummins A, Button J, Holt DW, Ramsey J, Dargan PI. Energy-1 (‘NRG-1'): don’t believe what the newspapers say about it being legal. Emerg Med J. 2011 Dec;28(12):1068-70.

Wood DM, Davies S, Cummins A, Button J, Holt DW, Ramsey J, Dargan PI. Energy-1 (‘NRG-1'): don’t believe what the newspapers say about it being legal. BMJ Case Rep. 2011 Feb 2;2011

Barkus E, Morrison PD, Vuletic D, Dickson JC, Ell PJ, Pilowsky LS, Brenneisen R, Holt DW, Powell J, Kapur S, Murray RM. Does intravenous ?9-tetrahydrocannabinol increase dopamine release? A SPET study. J Psychopharmacol. 2011 Nov;25(11):1462-8.

Wood DM, Stribley V, Dargan PI, Davies S, Holt DW, Ramsey J. Variability in the 3,4-methylenedioxymethamphetamine content of ‘ecstasy’ tablets in the UK. Emerg Med J. 2011 Sep;28(9):764-5.

Wood DM, Panayi P, Davies S, Huggett D, Collignon U, Ramsey J, Button J, Holt DW, Dargan PI. Analysis of recreational drug samples obtained from patients presenting to a busy inner-city emergency department: a pilot study adding to knowledge on local recreational drug use. Emerg Med J. 2011 Jan;28(1):11-3.

Wood DM, Davies S, Greene SL, Button J, Holt DW, Ramsey J, Dargan PI. Case series of individuals with analytically confirmed acute mephedrone toxicity. Clin Toxicol (Phila). 2010 Nov;48(9):924-7.

Ramsey J, Dargan PI, Smyllie M, Davies S, Button J, Holt DW, Wood DM. Buying ‘legal’ recreational drugs does not mean that you are not breaking the law. QJM. 2010 Oct;103(10):777-83.

Davies S, Wood DM, Smith G, Button J, Ramsey J, Archer R, Holt DW, Dargan PI. Purchasing ‘legal highs’ on the Internet–is there consistency in what you get? QJM. 2010 Jul;103(7):489-93.

Wood DM, Davies S, Puchnarewicz M, Button J, Archer R, Ovaska H, Ramsey J, Lee T, Holt DW, Dargan PI. Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicity. J Med Toxicol. 2010 Sep;6(3):327-30.

Wolff K, Johnston A. Cannabis use: a perspective in relation to the proposed UK drug-driving legislation. Drug Test Anal. 2014 Jan;6(1-2):143-54.

Dargan PI, Davies S, Puchnarewicz M, Johnston A, Wood DM. First reported case in the UK of acute prolonged neuropsychiatric toxicity associated with analytically confirmed recreational use of phenazepam. Eur J Clin Pharmacol. 2013 Mar;69(3):361-3.

Wood DM, Davies S, Puchnarewicz M, Johnston A, Dargan PI. Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine. Eur J Clin Pharmacol. 2012 May;68(5):853-6.

Wood DM, Puchnarewicz M, Johnston A, Dargan PI. A case series of individuals with analytically confirmed acute diphenyl-2-pyrrolidinemethanol (D2PM) toxicity. Eur J Clin Pharmacol. 2012 Apr;68(4):349-53.   Grossman SE, Johnston A, Vanezis P, Perrett D. Can we assess the age of bruises? An attempt to develop an objective technique. Med Sci Law. 2011 Jul;51(3):170-6.

Pilling ML, Vanezis P, Perrett D, Johnston A. Visual assessment of the timing of bruising by forensic experts. J Forensic Leg Med. 2010 Apr;17(3):143-9.